Abstract
The causes of acute renal insufficiency (ARI) were determined in 45 infants less than 2 months of age with oliguria. Seventeen (38%) infants responded to fluid challenge and were diagnosed as having pre-renal azotemia (PRA). Twenty infants (45%) had ischemic renal damage (ATN). Eight infants (17%) had renal failure from other causes. Though there were no differences in BUN and creat., infants with ATN had higher RFI than those with PRA.
Eleven of 20 (55%) infants with ATN died. Only 2 infants with obstructive uropathy developed chronic renal insufficiency. When grouped according to gestational age renal failure indices (RFI) in infants with ATN showed no significant differences.
Conclusions: 1) Since normal infants have elevated FENa, values above 3.0 must be used to differentiate ATN from PRA in neonates with ARI. 2) There is overlap with other causes of ARI. 3) Infants less than 2 months of age with PRA also have elevated FENa. 4) Though RFI increased with gestational age, this increase did not reach significance.
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Ellis, E., Arnold, W. & Fiser, R. 1496 USEFULNESS OF RENAL FAILURE INDICES IN NEONATAL RENAL FAILURE. Pediatr Res 15 (Suppl 4), 692 (1981). https://doi.org/10.1203/00006450-198104001-01525
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DOI: https://doi.org/10.1203/00006450-198104001-01525