Abstract
The most frequent cause of elevated serum [SO4] is reduced renal sulfate clearance secondary to decreased GF. We have observed that 1,25-(OH)2D3 treatment in man results in an increase of serum [SO4] that correlates inversely with decreased creatinine clearance (Ped. Res. 14,570, 1980). With osmotic mini-infusion pumps implanted subcutaneously into normal (+/Y) C57B1/6J adult male mice and their hypophosphatemic (Hyp/Y) littermates, we examined the effect of 1,25-(OH)2D3 treatment (83 ng/g·dy × 10 dy) on serum calcium and serum [SO4]. Sham-operated animals receiving propylene glycol only served as controls. 1,25-(OH)2D3 treatment in +/Y mice, resulted in significant hypercalcemia compared to controls: 11.34±.07 (n=8) vs 10.05±0.12 mg/dl (n=9), respectively; p <.001. Serum [SO4] was also elevated (1.35±.07 vs 1.17±.05 mmol/l; p <.025). In contrast, the same dose administered to the Hyp/Y mouse failed to change either serum Ca [9.57±.05 (n=6) vs 9.46±.05 mg/dl (n=6)] or SO4 (1.03±.02 vs 1.06±.07 mmol/l). These observations support the hypothesis that 1,25-(OH)2D3 reduces sulfate clearance (and presumably GF). This effect is apparently mediated by changes in serum calcium and is not necessarily the direct result of hormone action on glomerular filtration. This study indicates that avoidance of hypercalcemia will minimize adverse effects of 1,25-(OH)2D3 on renal function.
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Cole, D., Tenenhouse, H. & Scriver, C. 1491 ELEVATED SERUM SULFATE (SO4) AFTER l, 25-(OH)2D3 TREATMENT: A MARKER FOR DECREASED GLOMERULAR FILTRATION (GF) WITH HYPERCALCEMIA?. Pediatr Res 15 (Suppl 4), 691 (1981). https://doi.org/10.1203/00006450-198104001-01520
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DOI: https://doi.org/10.1203/00006450-198104001-01520