Abstract
Using a radioimmunoassay we measured [CKBB] in 130 CSF samples from 86 newborns. Infants with intraventricular hemmorhage(IVH) documented by computerized tomography(CT) had significantly higher [CKBB] in CSF than infants who had normal CT's or were not clinically suspected of having an IVH. [CKBB]'s are expressed in nanograms/ml.
Patients with a definitely abnormal neurological exam prior to the LP had significantly higher [CKBB] in CSF than those with suspect or normal exams.
All 15 infants with [CKBB]>25 ng/ml had suffered a severe neurological insult. (13 had an IVH and 2 had severe asphyxia.)
CSF [CKBB] is a metabolic indicator of brain damage and is significantly elevated in CSF from infants with IVH and abnormal neurological exams.
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Worley, G., Lipman, B., Gewolb, I. et al. 1467 CREATINE KINASE BRAIN ISOENZYME CONCENTRATION CKBB IN CEREBROSPINAL FLUID(CSF) OF NEWBORNS. Pediatr Res 15 (Suppl 4), 687 (1981). https://doi.org/10.1203/00006450-198104001-01496
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DOI: https://doi.org/10.1203/00006450-198104001-01496