Abstract
Asphyxia has been shown to adversely affect neonatal calcium and magnesium homeostasis. We studied the effect of asphyxia on renal calcium, magnesium and phosphate homeostasis in 12, 1-6 day old newborn lambs. In 6 lambs, hypoxemia, hypercarbia and acidosis was induced by a 38ml/kg deadspace added to the airway for 20 min; the study continued for 140 min; 6 non-asphyxiated lambs were controls. Changes in asphyxiated lambs are shown: U = urinary concentration, V = volume, TRP = tubular reabsorption P.
MĀ±SEM, *p<.05 compared to (B), +p<0.05 decrease compared to controls. Significant changes were not seen in control lambs. Thus, asphyxia induces hypermagnesemia and phosphaturia in newborn lambs; we speculate that magnesium may be released from intracellular stores and phosphaturia may be due to increased calcitonin or parathyroid release.
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Stonestreet, B., Laptook, A., Oh, W. et al. 1445 ASPHYXIA INDUCED ALTERATIONS IN SERUM AND RENAL CALCIUM, MAGNESIUM AND PHOSPHATE HOMEOSTASIS. Pediatr Res 15 (Suppl 4), 684 (1981). https://doi.org/10.1203/00006450-198104001-01474
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DOI: https://doi.org/10.1203/00006450-198104001-01474