1395 THE INFLUENCE OF AGE ON URANYL NITRATE (UN) NEPHROTOXICITY

Abstract

The newborn is more resistant to the nephrotoxic effects of aminoglycosides. To determine if this resistance extends to other nephrotoxins, we studied the effects of UN (10 mg/kg IV) on renal function in dogs 1-2 wks (I) and 3-5 wks (II) of age during initiation (2 hrs) and in the maintenance phase (24 hrs after UN). Age matched controls received saline(S). The results are:

2 hrs post UN, there was extensive vacuolation only of the pars convoluta and greater in II than in I. 24 hrs post UN there were no distinct morphological changes (light & electron microscopy). Conclusion: very young puppies are more resistant to some nephrotoxins than older puppies and adult dogs.

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Pelayo, J., Andrews, P., Calcagno, P. et al. 1395 THE INFLUENCE OF AGE ON URANYL NITRATE (UN) NEPHROTOXICITY. Pediatr Res 15, 675 (1981). https://doi.org/10.1203/00006450-198104001-01424

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