The newborn is more resistant to the nephrotoxic effects of aminoglycosides. To determine if this resistance extends to other nephrotoxins, we studied the effects of UN (10 mg/kg IV) on renal function in dogs 1-2 wks (I) and 3-5 wks (II) of age during initiation (2 hrs) and in the maintenance phase (24 hrs after UN). Age matched controls received saline(S). The results are:
2 hrs post UN, there was extensive vacuolation only of the pars convoluta and greater in II than in I. 24 hrs post UN there were no distinct morphological changes (light & electron microscopy). Conclusion: very young puppies are more resistant to some nephrotoxins than older puppies and adult dogs.
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Pelayo, J., Andrews, P., Calcagno, P. et al. 1395 THE INFLUENCE OF AGE ON URANYL NITRATE (UN) NEPHROTOXICITY. Pediatr Res 15, 675 (1981). https://doi.org/10.1203/00006450-198104001-01424