Abstract
Safety and age related immunogenicity of 2 HIB vaccines, prepared by Lederle Laboratories, polyribosylribitol phosphate (PRP) and PRP-pertussis (PRP-p) were compared in 3 groups of normal children aged 6-7 months,15-18 months and 3-6 years. Children in the older age groups received a single dose of 1 of the HIB vaccines or DPT. Children aged 6-7 months received either: 1) 2 monthly doses of an HIB vaccine, 2) DPT followed 1 month later by PRP or 3) PRP-p followed by DPT. Reactions were evaluated at 24 hours and RIA antibody (method of Anderson) determined at 1 month after injections. In the 2 older age groups,mild-moderate local and/or systemic reactions were similar for PRP-p (4/10 injections) and DPT (5/10 injections). PRP was without reactions. 6-7 month old children tolerated PRP-p and PRP equally well with 3/31 and 4/31 injections causing reactions. In contrast, 12/22 DPT injections caused reactions. Serologic responses to both HIB vaccines were age dependent. The ratio of post-pre geometric mean titers:
The addition of pertussis to PRP enhanced antibody response to the HIB polysaccharide antigen and holds promise as an approach to immunization.
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Wright, P., Burks, D., Pincus, D. et al. 1091 AGE RELATED RESPONSE TO HEMOPHILUS INFLUENZAE TYPE B VACCINES. Pediatr Res 15 (Suppl 4), 624 (1981). https://doi.org/10.1203/00006450-198104001-01117
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DOI: https://doi.org/10.1203/00006450-198104001-01117