Abstract
A trial was designed to determine the antigen and adjuvant composition for pertussis vaccine which would produce the least reactogenicity and the best antibody response (ABR). DPT preparations containing fluid (F) or whole cell (W) pertussis antigen and either alum (U) or AlPO4 (P) adjuvant were compared. Serologic data were collected on 42 patients; reactogenicity was assessed following 263 doses.
Although whole cell antigen produced a greater ABR it also resulted in increased febrile responses. Fever tended to be greater with increasing number of immunizations.
After the third dose local reactions were most frequent with the presently used vaccine (WP). This group also used Tylenol significantly more.
Based on these data consideration should be given to a new formulation for the pertussis component of DPT.
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Murphy, M., Rasnack, J., Deitch, H. et al. 1049 REACTOGENICITY AND IMMUNOGENICITY OF PERTUSSIS VACCINE COMPONENTS. Pediatr Res 15 (Suppl 4), 617 (1981). https://doi.org/10.1203/00006450-198104001-01075
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DOI: https://doi.org/10.1203/00006450-198104001-01075