Abstract
Alterations in platelet function in patients with sickle cell anemia (SCA) may contribute to vaso-occlusive crises. Since thrombocytosis may further enhance thrombotic tendencies, we investigated the occurrence rate, magnitude and adverse effects of thrombocytosis in children with SCA and pneumonia. In 37 patients, 47 episodes of pneumonia were evaluated. Platelet counts in 7 patients rose to greater than 1 × 106/mm3 and in 16 patients to ≥750,000/mm3. The mean platelet count began to rise on the fifth day. From day 7 to day 21 the average platelet count was greater than twice the average count on admission and during asymptomatic periods. There were no platelet aggregation abnormalities detected initially or after the development of thrombocytosis. The mean platelet volumes, determined on an electronic particle counter, also remained constant. Only one patient had a painful crisis during the duration of post-pneumonia thrombocytosis. His painful crisis resolved despite a continued rise in platelet count. Although thrombocytosis following pneumonia in patients with SCA is common, the risk of related vaso-occlusive sequelae appears low and anti-platelet therapy does not appear warranted.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Poncz, M., Groenberg, J., Russell, M. et al. 852 THROMBOCYTOSIS IN PATIENTS WITH SICKLE CELL ANEMIA AND PNEUMONIA. Pediatr Res 15 (Suppl 4), 584 (1981). https://doi.org/10.1203/00006450-198104001-00877
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-00877