Abstract
EBV infection has been associated with diseases ranging from infectious mononucleosis to X-linked lymphoproliferative syndrome. We have evaluated a 21-month-old white boy and a 15-month-old black girl with suspected JCML whose presenting features included lymphadenopathy, hepatosplenomegaly, decreased platelets and leukocytosis. Evaluation was negative for a malignant process. Representative immunologic studies of the patient blood cells included:
Antibodies to EBV viral capsid antigen and EBV early antigen persistently were elevated. Natural killer cell activity was diminished in both patients and showed little augmentation with fibroblast interferon. No EBV specific cytotoxicity was detected. The patients have been followed for 30 and 20 months on no therapy with clinical improvement. These patients have alterations in cell mediated immune responses and abnormal immunoregulation of antibody production to EBV. Because of their clinical presentation such patients need to be distinguished from those with true malignancies.
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Herrod, H., Dow, L., Sullivan, J. et al. 815 ABNORMAL IMMUNE RESPONSES TO EPSTEIN-BARR VIRUS (EBV) ASSOCIATED WITH AN ILLNESS MIMICKING JUVENILE CHRONIC MYELOGENOUS LEUKEMIA (JCML) IN TWO CHILDREN. Pediatr Res 15 (Suppl 4), 578 (1981). https://doi.org/10.1203/00006450-198104001-00840
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DOI: https://doi.org/10.1203/00006450-198104001-00840