Abstract
Recent experimental and clinical researches suggest that thymic humoral factors may be helpful in restoring immune balance in patients with T-cell defect. A calf thymic extract (TPl Serono Institute) induces the maturation of pre-T-cells and increases the capacity of mature T-cells to respond to antigen. Our previous investigations have shown a maturation of pre-T-cells in vitro,a clinical and immunological recostitution in primary T-cell defect after TP1 therapy.Now we have treated 10 children suffering from T-cell defect associated with severe viral infections,with TP1 75 mg/m2/day for a week and at the same dose twice a week for 3 months. Our results showed an increase of E-rosette forming cells after incubation of peripheral blood lymphocytes with TP1 in vitro and after 1 month of treatment in vivo (fig) Furthermore, during the therapy, a complete recovery of viral infections was observed in all subjects.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rossi, P., Quinti, I., Galli, E. et al. THYMOSIN (TPl) THERAPY IN PATIENTS WITH SEVERE VIRAL INFECTIONS AND T-CELL DEFECT: 5. Pediatr Res 14, 167 (1980). https://doi.org/10.1203/00006450-198002000-00032
Issue Date:
DOI: https://doi.org/10.1203/00006450-198002000-00032