The purpose of this study is to report the findings of CIC using Polyethylene glycol precipitation technique(PEG)and modified variant of inhibition of RF Latex agglutination test(RF-inh.)in 18 patients with APSGN,in 18 postnephritic children who recovered from the acute phase of APSGN 2-4 years earlier and 18 patients with SSNS.
CIC were found in 14/18 patients with APSGN when tested during the first three weeks of the disease using PEG and in 11/13 using RF-inh.Sequential determination of CIC showed the highest values of CIC within 3-5 weeks of the disease.In acute phase gross hematuria was found in 13/14 patients with CIC and only in 1/4 without CIC;there was no difference in severity of proteinuria and serum creatinine.In 18 postnephritic children CIC were not found.In patients with SSNS,CIC were found in 12/14 while relapsing.During the follow-up these 12 patients had 26 relapses and CIC were found in 17/26 and 10/21 using PEG and RF-inh. respectively.In remission CIC were found only occasionally.
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Popović-Rolović, M., Živanović, L., Nikolić, V. et al. CIRCULATING IMMUNE COMPLEXES(CIC) IN ACUTE POSTSTREPTOCOCCAL GLOMERULONEPHRITIS(APSGN) AND STEROID SENSITIVE NEPHROTIC SYNDROME (SSNS). Pediatr Res 14, 1013 (1980). https://doi.org/10.1203/00006450-198008000-00241