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CIRCULATING IMMUNE COMPLEXES(CIC) IN ACUTE POSTSTREPTOCOCCAL GLOMERULONEPHRITIS(APSGN) AND STEROID SENSITIVE NEPHROTIC SYNDROME (SSNS)

Abstract

The purpose of this study is to report the findings of CIC using Polyethylene glycol precipitation technique(PEG)and modified variant of inhibition of RF Latex agglutination test(RF-inh.)in 18 patients with APSGN,in 18 postnephritic children who recovered from the acute phase of APSGN 2-4 years earlier and 18 patients with SSNS.

CIC were found in 14/18 patients with APSGN when tested during the first three weeks of the disease using PEG and in 11/13 using RF-inh.Sequential determination of CIC showed the highest values of CIC within 3-5 weeks of the disease.In acute phase gross hematuria was found in 13/14 patients with CIC and only in 1/4 without CIC;there was no difference in severity of proteinuria and serum creatinine.In 18 postnephritic children CIC were not found.In patients with SSNS,CIC were found in 12/14 while relapsing.During the follow-up these 12 patients had 26 relapses and CIC were found in 17/26 and 10/21 using PEG and RF-inh. respectively.In remission CIC were found only occasionally.

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Popović-Rolović, M., Živanović, L., Nikolić, V. et al. CIRCULATING IMMUNE COMPLEXES(CIC) IN ACUTE POSTSTREPTOCOCCAL GLOMERULONEPHRITIS(APSGN) AND STEROID SENSITIVE NEPHROTIC SYNDROME (SSNS). Pediatr Res 14, 1013 (1980). https://doi.org/10.1203/00006450-198008000-00241

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