Abstract
To know the influence of steroid on CNS in nephrotic S.,CSF-space/Intracranial space ratio(abb.C/T-R)was calculated by computor processing of CT at the level of the 3rd and lateral ventricles in 14 cases of nephrotic S.(MC 10;PGN 3;SHS 1;chr.sclerosinq 1)
Twelve of 14 cases treated with steroid revealed abnormaly high C/I-R than controls(non nephrotic,non steroid Tx,mean C/I-R=1.6±0.8 SD.). Nine of 12 cases with abnormaly high C/I-R. showed normal C/I-R after the withdrawal of steroid,reduction or during the end of maintenance therapy by alternate-day regimen.
Abnormal neurological and psychiatric symptoms in the above 16 cases were 2 manic;l depressive state;muscle weakness in 4;tremor of the finger 1,although no correlation with the grade of C/I-R abnormalities. C/I-R was the highest in a case with para or β methasone therapy for 2.5 months. C/I-R showed no relationship between the age or sex of the patients.
The above data suggest that massive dose of steroid might have apparent cerebral atrophic effect although it will be reversible.
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Yamashita, F., Yano, E., Yamamoto, M. et al. APPARENT CEREBRAL ATROPHY ON COMPUTED TOMOGRAPHY IN NEPHROTIC CHILDREN WITH STEROID THERAPY. Pediatr Res 14, 1007 (1980). https://doi.org/10.1203/00006450-198008000-00205
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DOI: https://doi.org/10.1203/00006450-198008000-00205