Abstract
The subjects of this study consisted of, the First Group which was of 60 cases of acute poststreptococcal GN - which was further classified into the First Group-A which was of 37 cases who had been cured within 12 months and the First Group-B whose cure had taken more than 12 months (23 cases); and the 2nd Group consisting of 129 cases found to have primary GN (chance proteinuria and/or hematuria) at a regular physical examination by urine test, of whom, 22 cases were of chronic GN (2nd Group-A). The typing of the HLA antigens were done in the method of Terasaki's microdroplet lymphocyte cytotoxity. RESULTS: In the First Group-A, there was not a difference in frequencies of the antigen while significant increase of HLA-B12 was observed in the First Group-B (x2=16.6), showing a distinct difference from the First Group-A. In the 2nd Group, also, significant increase of HLA-B12 was observed (X2=14.0). In the 2nd Group-A, correlation of HLA-B12 was more significant (X2=27.8).
CONCLUSION: From the fact that the common correlation with the specific HLA antigen, that is HLA-B12, between the asymptomatic GN which is found by group urine test such as the case of school children's regular examination and the acutely caused nephritis which delays in cure, it seems possible to assume that these are etiologically considered to be the same type of disease and that HLA-B12 or it's related genes can be responsible for causing and delaying the cure of Glomerulonephritis.
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Ito, S., Shimakura, Y., Tomizawa, S. et al. IMMUNOGENETIC ASPECT IN THE PATIENTS WITH GN. Pediatr Res 14, 1004 (1980). https://doi.org/10.1203/00006450-198008000-00185
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DOI: https://doi.org/10.1203/00006450-198008000-00185