Abstract
Purpose: Study on relationship between long-term prognosis and renal histopathological findings of INS. Methods: Seventy-nine patients with INS performed renal biopsy during 1958 to 1978, were followed up. Sixty-five out of 79 patients were followed up for ten or more years. Our histopathological classification is much the same as that by ISKDC. The disease status or response to treatment was recorded at 6 months, 1, 2, 5, 10 and 15 years, respectively, after the initial administration of corticosteroids.
Results: The patients with minimal chage or mesangial proliferative glomerulonephritis had a favorable outcome, even those with hematuria. No relapse was found among patients over 20 years of age. Long-term outcome in other renal histopathological groups, especially in MPGN, was poor.
Conclusions: The long-term prognosis of INS in childhood is closely related to the type and severity of renal lesions, and the histopathological findings of renal tissue provides an essential diagnostic and prognostic information for the care of individuals.
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Fujisawa, S., Miyazaki, R., Okuhara, K. et al. LONG-TERM FOLLOW-UP STUDY OF IDIOPATHIC NEPHROTIC SYNDROME (INS) IN CHILDHOOD. Pediatr Res 14, 1001 (1980). https://doi.org/10.1203/00006450-198008000-00167
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DOI: https://doi.org/10.1203/00006450-198008000-00167