Abstract
The kidney biopsies of 25 children with MCNS were evaluated retrospectively to determine whether there is any correlation between the histological subgroups and the frequency of relapses. Biopsy material was examined by conventional LM, semithin sections, EM and morphometry. The frequently relapsing group (FR) comprised 15 and the non- or infrequent relapsing group 10 patients (IR).FR had been followed for longer periods before biopsy (mean 4 yrs.) than IR (1.4 yrs.). Mild mesangial hypercellularity and focal tubular atrophy were more common in FR (5/15) than in IR (1/10). In morphometric studies of semithin sections the number of mesangial nuclei per 1000 um2 mesangial area was significantly increased in FR compared to IR ( mean 9.40±0.28 S.E. vs. 8.04±0.23 S.E.; p<0.005). By electron microscopy no difference was found concerning the presence of unspecific electrondense deposits, podocyte changes or glomerular basement membrane lesions. Morphometric measurement of mesangial alterations appears to be a promising method for exploring clinicopathological correlations in steroid-sensitive MCNS.
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Waldher, R., Fydhy, K., Mal, L. et al. MESANGIAL CHANGES IN STEROID-SENSITIVE MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS). A CLINICOPATHOLOGIC AND MORPHOMETRIC STUDY. Pediatr Res 14, 1001 (1980). https://doi.org/10.1203/00006450-198008000-00166
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DOI: https://doi.org/10.1203/00006450-198008000-00166