RENAL OSTEODYSTROPHY IN CHILDREN: THERAPY WITH VITAMIN D3 OR 1,25 DIHYDROXY-CHOLECALCIFEROL (1,25-DHCC)

Abstract

Growth arrest and renal osteodystrophy is a major problem in renal insufficiency of children.The present report describes our experiences in managing renal osteodystrophy in 16 children on maintained hemodialysis treatment by using vitamin D3 for 12 to 18 months and in 14 dialyzed children by using 1,25-DHCC for 12months In treatment with vitamin D3 plasma-Ca,alkaline phosphatase and iPTH normalized nearly.Radiographic abnormalities improved.Bone biopsies showed improvement in signs of secondary hyperparathyreodism and ostitis fibrosa,whereas osteomalacia remained unchanged and osteoblast population showed a small reduction.No real increment in body growth was seen.In treatment with 1,25-DHCC alkaline phosphatase and iPTH normalized completely.Radiographic examinations revealed marked improvement.Histological signs of fibroosteoclasia and resorptive defects disappeared but there was no recovery of osteomalacia.A reduction of osteoblast population and of bone transformation was obvious.1,25-DHCC,also,failed to normalize growth in uremic children.Summarizing,neither vitamin D3 nor 1,25-DHCC can guarantee complete recovery of renal osteodystrophy and growth arrest in uremic children.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ziegler, R., Bulla, M., Delling, G. et al. RENAL OSTEODYSTROPHY IN CHILDREN: THERAPY WITH VITAMIN D3 OR 1,25 DIHYDROXY-CHOLECALCIFEROL (1,25-DHCC). Pediatr Res 14, 990 (1980) doi:10.1203/00006450-198008000-00103

Download citation

Further reading