13 biopsies (A) from cryptorchid boys treated previously with LH-RH nasal spray were obtained during orchidopexy. For comparison 14 biopsies (B) from cryptorchid boys unsucessfully treated with HCG and 10 biopsies (C) without treatment were also obtained during surgery and examined by light and electromicroscopy. All boys were of the same chronological age: A (2.9 ± 1.8), B (2.6 ± 0.9) and C (3.0 ± 1.5) years old. The normal descendent testicle has 1.4 ± 0.3 spermatogonia per tubulus while cryptorchid boys had significantly lower spermatogonia tubulus (A - 0.38 ± 0.5; B - 0.43 ± 0.7; C - 0.35 ± 0.5) . There was no significant difference between the three groups concerning the number of spermatogonia. This observation shows that neither HCG-therapy (5000 El for 5 weeks) nor LH-RH-therapy (1.2 mg/day for 4 weeks) have a stimulatory effect on germ cells. The results also demonstrate that there are no anti-fertility effects of LH-RH therapy. The most striking feature of Leydig cells after LH-RH treatment is the marked increase of cell size and smooth endoplasmic reticulum. These changes were identical to those observed after HCG treatment. Ultrastructurally, the Leydig cells show signs of stimulation and increased secretory activity following LH-RH or HCG treatment for cryptorchidism.
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Hadziselimovic, F., Hocht, B., Herzog, B. et al. Reproductive Capacity and Ultrastructure of Testis after LH-RH or HCG Therapy for Cryptorchidism. Pediatr Res 13, 1191 (1979). https://doi.org/10.1203/00006450-197910000-00068
Langenbecks Archiv f�r Chirurgie (1983)