Abstract
Granulocytes from a 6 year old boy with congenital transcobalamin II deficiency were found to have abnormally low antibacterial activity against Staphylococcus aureus and very low intracellular levels of the cobalamin coenzymes. Transfusion of normal plasma supplemented with hydroxocobalamin temporarily restored granulocyte bactericidal activity to normal and increased cellular levels of the cobalamin coenzymes. Granulocyte function was also temporarily restored by oral leucovorin. The defect appears to be causally related to the patient's TC II deficiency and indirectly to a deficiency of cobalamin and folate coenzymes.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seger, R., Wildfeuer, A., Frater-Schröder, M. et al. 40 THE ROLE OF VITAMIN B12 AND ITS TRANSPORT GLOBULINS IN GRANULOCYTE BACTERIAL KILLING. Pediatr Res 13, 954 (1979). https://doi.org/10.1203/00006450-197908000-00056
Issue Date:
DOI: https://doi.org/10.1203/00006450-197908000-00056