Abstract
The large number (>15) and frequency (∼2%) of rare placental alkaline phosphatase (P1) alleles represent a very special case among polymorphic enzymes. Since the P1 gene is active only during intrauterine life, the allelic diversity and its maintenance may be connected with intrauterine environment and with fetal development. 1700 newborn infants (1271 Caucasians, 337 Negroes and 92 Puerto Ricans), collected at Yale-New Haven Hospital from 1968-1971, were studied. An analysis of the relationship between rare P1 phenotype and the following 14 variables was carried out: gestational age, birth weight, maternal age, gestational order, sex, fetal and maternal ABO and Rh phenotype, feto-maternal ABO and Rh compatibility, fetal phosphoglucomutase 1 and 3 phenotype, and previous spontaneous abortions. A negative association between rare P1 phenotype and maternal 0 phenotype (p<0.05) was observed in all ethnic groups. The incidence of rare P1 types appeared to increase in the births following the first one and to decrease in those of higher order.
(Supported by NATO Grant 554).
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Gloria-Bottini, F., Polzonetti, A., Bentivoglia, K. et al. 526 RARE PHENOTYPES OF PLACENTAL ALKALINE PHOSPHATASE: AN ANALYSIS OF RELATIONSHIPS WITH SOME NEONATAL AND MATERNAL VARIABLES. Pediatr Res 12 (Suppl 4), 451 (1978). https://doi.org/10.1203/00006450-197804001-00531
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DOI: https://doi.org/10.1203/00006450-197804001-00531