Abstract
Indirect calorimetry and urinary nitrogen excretion has been used to define the proportions of AA, GL and fat oxidised during TPN over >3 hr. periods under thermoneutral conditions in 14 appropriately grown infants between lKg.-3.6Kg. in weight, 27-41 wks. gestational age, from 7-48 days postnatal age. Selected results:
During AA/GL infusion 64% of Kilocalories(Kcal.) were derived from carbohydrate(CH20). Following isocaloric lipid infusion 82% of Kcal. were derived from lipid oxidation demonstrating metabolic flexibility according to substrate available. This change was accompanied by a 15% increase in metabolic rate and a heat storage of 4.1 Kcal/Kg.d. Further studies showed that, below 60Kcal/Kg.d there was a proportionately increased endogenous fat and AA oxidation. At levels > 70 Kcal/Kg.d endogenous fat oxidation became negligible and AA oxidation was minimised.
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Putet, G., Heim, T., Smith, J. et al. 460 SUBSTRATE UTILISATION DURING ISOCALORIC, ISOVOLAEMIC PARENTERAL NUTRITION (TPN) WITH GLUCOSE/AMINO-ACID(GL/AA) AND FAT EMULSION(IL). Pediatr Res 12 (Suppl 4), 440 (1978). https://doi.org/10.1203/00006450-197804001-00465
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DOI: https://doi.org/10.1203/00006450-197804001-00465