457 THE EFFECT OF POSTNATAL AGE ON THE METABOLISM OF INTRAVENOUS FAT EMULSION

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Abstract

To determine the effect of postnatal age on serum clearing of intravenous fat, 17 preterm, AGA infants with gestation age of 29 ± 0.4 SEM wks. and birthweight of 1.2 ± 0.07 SEM kg. and less than 3 wks. of age received 1 gm/kg of Intralipid over a 4 hour infusion. Plasma levels of triglyceride (TG), free fatty acids (FFA) and beta-hydroxibutyrate (BOB) were determined at 0, 4, and 8 hours after the infusion was started. Basal levels of TG, FFA, and BOB were similar in the 2 groups. Infants of less than 1 wk. old had higher peak TG levels at the end of the infusion (4 hr.), than infants 2-3 wks. old (p<0.01). 8 hours after the beginning of the infusion TG levels remained significantly higher in the younger group (p<0.05).

The rise in TG levels seen in our older group was lower than that (reported in infants of less than 33 wks. of gestation and comparable with levels obtained from infants of more than 33 wks. of gestation studied within the first 48 hours from birth. This suggests an acceleration in the capacity to tolerate intravenous fats after the first week of extra-uterine life.

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