Abstract
Our previous observations in 435 children demonstrated that the one-hour blood xylose test is a reliable index of small bowel mucosal function (J. Ped., in press). In this study on CMPI, 11 children (aged 3-24 months) suspected of CMPI and making good progress on a milk-free gluten-containing diet were challenged after 4-10 weeks with whole cow's milk (CM). A base line study in all patients consisted of: 1- one-hour blood xylose test, 2- serum IgE, 3- serum complement (C3), 4- eosinophilic count, 5- jejunal biopsy for histology and disaccharidase activity. Four to six days after reintroduction of CM, the first four parameters were measured again and a second jejunal biopsy performed in 7 patients. Seven patients reacted clinically to the milk. No significant changes were observed in serum IgE, C3 complement and eosinophilic count. A significant drop of 51% to 77% in the one-hour blood xylose level was observed in all patients. Mean value (±SEM) for the whole group was 46.1±2.0 mg/dl before and 17.4±1.3 mg/dl following CM. Pre-challenge biopsy specimens for histology and disaccharidase activities were normal in all patients. Histologic changes were observed in the post-challenge biopsies of five patients. Statistically significant decreases in lactase, sucrase and maltase activities occurred after CM. This study suggests that the one-hour blood xylose test is a simple and valuable test in the diagnosis of CMPI.
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Morin, C., Buts, JP., Weber, A. et al. 455 ONE-HOUR BLOOD-XYLOSE TEST IN THE DIAGNOSIS OF COW'S MILK PROTEIN INTOLERANCE (CMPI). Pediatr Res 12 (Suppl 4), 439 (1978). https://doi.org/10.1203/00006450-197804001-00460
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DOI: https://doi.org/10.1203/00006450-197804001-00460