Abstract
A simple and reliable means of detecting abnormal GER in children is needed. A radionuclide method was evaluated in a series of 25 patients with documented GER (positive pH reflux test). Symptomatic patients with abnormal pH reflux test (pH < 4.0) were studied. With the patient supine or semi-upright, 200 uci of TC-99m sulfur colloid in apple juice was given orally. Patients were allowed to drink until sated (volume 60-300cc). Gamma camera images were then made in the basal state, with hand pressure and at graded increments of external abdominal pressure (blood pressure cuff around abdomen) up to 100 mm Hg. Any visible activity in the esophagus was interpreted as an abnormal test. In addition, all patients had lower esophageal sphincter pressure (LESP) determinations as well as barium cine-gastroesophagograms.
The radionuclide study was easy to perform and well tolerated. Evidence of reflux was detectable in 20 patients using this method. The LESP was 12 mm Hg or less in 14 patients. The barium x-ray study was abnormal in 15 patients.
Radionuclide gastroesophagography is a sensitive technique for detecting GER in infants and children. Additional studies to further assess clinical utility and specificity appear warranted.
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Christie, D., Rudd, T. & Kelley, V. 409 RADIONUCLIDE TEST FOR GASTROESOPHAGEAL REFLUX (GER) IN CHILDREN. Pediatr Res 12 (Suppl 4), 432 (1978). https://doi.org/10.1203/00006450-197804001-00414
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DOI: https://doi.org/10.1203/00006450-197804001-00414