Abstract
Effects of the muscular relaxant Pancuronium (P) were investigated in piglets under anesthesia with 0.25% halothane in N2O and O2. Artificial ventilation was adjusted to maintain normal arterial pH and PCO2. Control values for all animals were pH 7.432±0.1 and PCO2 34.4±1.3. Aortic pressure (AoP), heart rate (HR) and femoral and carotid flows (F) were recorded simultaneously in 17 animals in 3 age groups (6≥2 days, 5 at 1 week and 6 at 2 weeks). Resistance (R) was calculated at mean AoP/mean F. Single doses totaling 90.4±2.1 μg P/kg, which approximates the clinical dosage in infants up to 3 weeks of age, were injected into the right atrium. Different effects on ≥ were observed between the ≥ day and 2 week old piglets. ≥ increased 7.9%±3.0 in the youngest and 20.5%±4.7 in the oldest. HR changes were not systematic in the youngest animals. However, HR significantly increased 17.4%±2.1 in 2 week olds. Femoral and carotid F increased in all animals while R varied. In contrast to our results with decamethonium bromide (Crane, L., et al. Archint. Pharmacodyn. 208:52, 1974), P never produced hypotension, thereby emphasizing P's greater clinical usefulness. (Supported by the Nassau Heart Assoc.)
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Gootman, N., Buckley, B. & Nagelberg, J. 253 CARDIOVASCULAR EFFECTS OF PANCURONIUM IN ANESTHETIZED NEONATAL PIGLETS. Pediatr Res 12 (Suppl 4), 406 (1978). https://doi.org/10.1203/00006450-197804001-00258
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DOI: https://doi.org/10.1203/00006450-197804001-00258