Abstract
We have shown previously that furosemide (FU) stimulates secretion of renin and arginine vasopressin (AVP) in the newborn lamb. Nephrectomy abolished the plasma renin activity (PRA) and AVP responses, and saralasin acetate, an angiotensin II inhibitor, blocked the AVP response, suggesting that the AVP stimulation by FU is mediated by angiotensin II. The present study was designed to assess whether FU influences the renin-angiotensin-AVP system in the fetus. Seven fetal lambs 120-142 days gestational age and 6 newborn lambs were studied (term = 145 days). FU (2 mg/kg estimated fetal weight) was infused over 1-2 min. Blood samples were drawn at 8, 20, 35, and 65 min. post infusion. In the fetal lambs the M and SEM PRA (ng/ml/hr) increased from 10.0 ± 3.3 to 12.5 ± 3.6 at 8 min. (p<.05), 16.8 ± 4.4 at 20 min. (p<.01) and 24.3 ± 5.1 (p<.01) at 35 min. post FU. In the newborn lambs PRA increased from a base of 16.7 ± 5 to 41.8 ± 6 (p<.01) 20 min post FU and remained high. The M and SEM plasma AVP (μU/ml) increased 30 min. after PRA from a baseline of 2.1 ± 0.5 to 5.7 ± 1.8 (p<.05) 35 min. and 6.1 ± 1.4 (p<.05) 65 min. post FU in the fetal lambs. In the newborns AVP increased from a baseline of 2.7 ± 0.5 to 9.9 ± 3.4 (p<.05) 35 min and 13.9 ± 4.4 (p<.05) 65 min post FU Plasma sodium, Hct, and osmolality did not change. Conclusions: 1) FU stimulates the renin-angiotensin-AVP system in the fetal lamb after 120 days gestation; 2) fetal responsiveness is less than in the newborn animal.
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Sieqel, S., Weitzman, R. & Fisher, D. 213 FUROSEMIDE STIMULATION OF THE RENIN-ANGIOTENSIN-VASOPRESSIN SYSTEM IN THE FETAL LAMB. Pediatr Res 12 (Suppl 4), 399 (1978). https://doi.org/10.1203/00006450-197804001-00218
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DOI: https://doi.org/10.1203/00006450-197804001-00218