Abstract
1427 random urine specimens of 135 patients (age: newborn (NB) to 22 years) were analyzed for cAMP, cGMP, creatinine. Results in nanomoles/mg creatinine were on (*) single urine samples (-highest/lowest-values); others as mean values; and, for AGE; time of day -DAY:
By age 15y adult nucleotide concentration is attained at approx. 25% of newborn values. Statistical correlation between cAMP and cGMP for age was r = 0.96; for time of day r = 0.69; and none for sex. Extreme values occurred in complex disease states. cAMP high: intractable diarrhea; low: progressive CNS disease. cGMP high: multiple sulfatase deficiency; low: Reye's syndrome. Extremes may reflect pathophysiologic mechanisms in these conditions. Mean “normal” values served to assess nucleotide response (or lack of it) to glucagon or PTH in diseases such as glycogenoses or pseudohypoparathyroidism.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Newport, M., Hug, G. 205 CYCLIC AMP AND cGMP: URINARY EXCRETION FROM BIRTH TO ADULTHOOD. Pediatr Res 12 (Suppl 4), 398 (1978). https://doi.org/10.1203/00006450-197804001-00210
Issue Date:
DOI: https://doi.org/10.1203/00006450-197804001-00210