Abstract
Four groups of two week old lambs were exchange transfused (E.T.) after chronic catheterization. Five lambs, Group I, served as controls; 4 lambs, Group II, received fresh, settled maternal blood; 4 lambs, Group III, received fresh, packed maternal blood and 6 lambs, Group IV, received fresh, packed fetal blood. Cardiac output (C.O.), arterial and venous PO2, hematocrit (Hct) and P50 were measured before and two hours after E.T. No significant changes were noted in Group I for all parameters. Mean values for C.O. decreased in all groups following the E.T. (Gr. II by 57% (p < 0.01); Gr. III by 14% (p < 0.05); Gr. IV by 34% (p < 0.025). There were no changes in mean PaO2 in any of the groups; however, mean PvO2 increased in Gr. II by 13% (p < 0.05), and decreased in Gr. IV by 7% (p < 0.025). Mean Hct increased in Gr. II, III and IV by 10%, 48% and 36% (p < 0.0025) and mean P50 increased in Gr. II and III by 59 and 43%. These data indicate that with no change in P50 but increased Hct the resulting decreased PvO2 is in response to a decreased C.O., theoretically compromising O2 transport to the tissues. With an increased Hct, the decreased C.O. results in no change in PvO2 presumably counteracted by the increased P50. In contrast, increased P50 and moderate increased Hct (10%) results in increased PvO2, presumably facilitating O2 transport to the tissues, while maintaining a decreased C.O., thus reducing circulatory demands.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Delivoria-Papadopoulos, M., Anday, E., Llpton, E. et al. 178 VARIATIONS OF BLOOD OXYGEN AFFINITY AND CONTENT ON CARDIAC OUTPUT (C.O.) AND OXYGEN TRANSPORT TO THE TISSUES IN NEWBORN LAMBS. Pediatr Res 12 (Suppl 4), 393 (1978). https://doi.org/10.1203/00006450-197804001-00183
Issue Date:
DOI: https://doi.org/10.1203/00006450-197804001-00183