Abstract
In several recent studies, left ventricular muscle mass (LVMM) was derived from echocardiographic (ECHO) measurements in adults No such studies were reported in children. The purpose of this study is to establish normal LVMM values in children and to determine if this measurement is sensitive to detect the increased LVMM in patients with sickle cell disease (SS). Echocardiograms were performed in 251 children ages 3-17 yrs. (White (W)-107, Black (B)-97, and SS-47). LVMM in diastole and systole was derived by subtracting the volume of ventricular cavity from the volume occupied by the ventricular wall, septum and cavity. The volumes were calculated by three methods: 1. The cubed-function (C) of the given left ventricular ECHO diameter and by the modified methods of 2. Teichholz (T) and 3. Ratshin (R). The values for the diastolic LVMM (gm/M2; mean ± SD) are tabulated:
The LVMM in systole, in each age and sex subgroup and percentile distribution, as well as its relationship to level of hemoglobin in SS (not shown in abstract) will be presented. The data suggest that each method can detect the increased LVMM in SS patients. The C and T methods should be used for quatitating LVMM in children because of low mean values with the wide scatter of normal LVMM derived by the method of R.
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Rao, P., Thapar, M., Haggard, R. et al. 150 LEFT VENTRICULAR MUSCLE MASS BY ECHOCARDIOGRAM IN CHILDREN. Pediatr Res 12 (Suppl 4), 388 (1978). https://doi.org/10.1203/00006450-197804001-00155
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DOI: https://doi.org/10.1203/00006450-197804001-00155