ANABOLIC EFFECT AND HORMONAL RESPONSE DUE TO PARENTERAL AMTNO ACID NUTRITION OF PREMATURE INFANTS

Article metrics

Abstract

Since prognosis of neonatal diseases, especially RDS, in premature infants is impaired by nitrogen imbalances, we compared the effect of 3 amino acid mixtures(AA) on nitrogen balance, blood glucose(BG), plasma insulin(IRI), human growth hormone(HGH), glucagon and cortisol. 3 AA-mixtures were supplied i.v. : A) AA/sorbitol/xylitol each 5g/100ml, B) AA 5g/100ml, C) AA 5g /glucose 10g/100ml. RESULTS: In all 3 groups nitrogen balance immediately became positive. BG showed a mild elevation in group A, no change in B and a sharp rise up to 180mg% after 60 min, in C. IRI corresponded well with BG in A and B. C showed an excessive IRI-rise(104 uU/ml after 60 min.). Glucagon was not affected in A and C. In B there was a rise up to 273pg/ml after 60min. HGH was well stimulated in all groups with an average maximum of 43ng/ml after 60 min. Cortisol showed mean levels of 6ug/100ml without significant change. CONCLUSION:AA-infusions and reactively high endog. HGH lead to pos.nitrogen balance. AA did not affect IRI, glucagon and cortisol reaction.

Author information

Rights and permissions

Reprints and Permissions

About this article