Abstract
A combined test of anterior pituitary function was performed in 29 growth hormone (HGH) treated children. Plasma ACTH(RIA) was measured at 0 and 40 min. and cortisol (isotope derivative techn.) at 0, 20 and 40 min. after insulin (+TRH + LHRH). – Basal values for ACTH were identical in the 3 groups: I: 13 HGH treated children with “borderline” HGH response - II: 16 HGH treated children without HGH response - and III: 12 normal children(with short stature and/or delayed puberty) with normal HGH response to hypoglycaemia. 40 min. ACTH values were normal in group I (1 of 13 was below 100 pg/ml) and subnormal in group II (4 of 16 were above 100 pg/ml).
9 of 10 children with 40 min .ACTH value above 100 pg/ml in group I had 40 min. cortisol values above 18 μg/100 m1.8 of 11 (II) had corresponding low values for ACTH and cortisol
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Petersen, K. ACTH and cortisol response to insulin hypoglycaemia in children with hypopituitary dwarfism. Pediatr Res 12, 1099 (1978). https://doi.org/10.1203/00006450-197811000-00107
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DOI: https://doi.org/10.1203/00006450-197811000-00107