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Deoxycorticosterone(DOC) and 18Hydroxy DOC (18OHDOC) in Childhood


Plasma DOC and 18OHDOC and urinary tetrahydroDOC (THDOC),free DOC, and 18OHDOC (per m2/24h) were measured by radioimmunoassay in children with no endocrinopathies (age 6m-18yr). No hormonal differences were seen between the different age groups. The effects of dietary sodium changes, ACTH(60U/24h), and dexamethasone (2mg/24h),and the findings in 17- and 11-hydroxylase deficiencies are summarized below:

Conclusions: 1)Plasma DOC and urinary THDOC,free DOC, and 18OHDOC remain constant throughout childhood. 2)DOC and 18-OHDOC are regulated mainly by ACTH. 3)Measurement of DOC and 18OHDOC is useful in the diagnosis of 17- and 11-hydroxylase deficiency. 4)Impaired 18-hydroxylation in 11-hydroxylase defect may indicate that 18- and 11-hydroxylation involve the same enzyme in the zona fasciculata.

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Rauh, W., Gottesdiener, K., Sonino, N. et al. Deoxycorticosterone(DOC) and 18Hydroxy DOC (18OHDOC) in Childhood. Pediatr Res 12, 1097 (1978).

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