Abstract
Twenty healthy children without any endocrine or metabolic disorders received 5 ug/kg bv:. cyclic GRIF in single dose i.v. Saline infusion was given to five children using control. The serum GH content was measured in the first three hours after the injection. The lowest values were obtaiaed in the fifth and the ninetieth minutes, the highest ones in the thirtieth, hundredfiftieth and hundred eightieth minutes. Eigtheen of twenty GH reserve was demonstrable./ 5 ng/ml/The difference between the effect of GRIF end saline was significant. Rebound of GH is described after a single /bolus/ small dose GRIF in healthy children with a standardized radioimmunoassay method. The suppression of GH secretion with exogenous GRIF can start a contraregulation in the way of CRF and the struggle between endojenous GRF and GRIF resultes in a second GH peak.
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Péter, F., Szentistványi, Z. & Brook, C. Effect of single small dose Somatostatin/GRIF/ on growth hormone release in children. Pediatr Res 12, 159 (1978). https://doi.org/10.1203/00006450-197802000-00079
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DOI: https://doi.org/10.1203/00006450-197802000-00079