Abstract
Maternal diabetes has been associated with an increased incidence of hyaline membrane disease. We have studied this relationship in rabbit does injected with alloxan and then mated. A total of 26 litters were studied. Fetuses from saline-injected control and diabetic litters were examined at 27.5 and 29.5 days gestational age. Pressure-volume curves were performed and surfactant from alveolar lavage fluid was quantified on a surface balance. Blood sugars of diabetic does ranged from 175-400 mg/dl throughout pregnancy as compared with 80-120 mg/dl in the controls.
We conclude that fetuses of diabetic rabbits have less deflation stability and quantitatively less surfactant when born prematurely but these effects are diminished close to term.
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Sosenko, I., Lawson, E., Demottaz, V. et al. 1231 DELAYED LUNG MATURATION IN FETUSES OF ALLOXAN DIABETIC RABBITS. Pediatr Res 12 (Suppl 4), 569 (1978). https://doi.org/10.1203/00006450-197804001-01237
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DOI: https://doi.org/10.1203/00006450-197804001-01237