Abstract
36 infants treated from Oct. 76 to Dec. 77 with pressure limited ventilation for respiratory failure in HMD had a 25% incidence of pulmonary air leak (PAL). Mortality was 80% with PAL, 20% without. PAL occurred at <48 hrs. in 8/9.
PAL was common in patients who had sustained PaCO2 < 40 mm Hg (mechanical over ventilation - MOV) and whose FiO2 and breaths per minute were lowered rather than peak airway pressure, as PaO2 improved. 5/6 of the infants with early ventilation who died without MOV were severely asphyxiated at 1 min (Apgar ≤ 3) compared with 1/5 of the infants who died with MOV. Deaths in Non-MOV infants may be associated with adverse perinatal factors predisposing the lung to injury.
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Herschel, M., Henry, M., Merisalo, R. et al. 1189 MECHANICAL OVER VENTILATION (MOV) AS A FACTOR IN PULMONARY AIR LEAK (PAL). Pediatr Res 12 (Suppl 4), 562 (1978). https://doi.org/10.1203/00006450-197804001-01195
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DOI: https://doi.org/10.1203/00006450-197804001-01195