Abstract
Intralipid is widely used for parenteral nutrition of infants with respiratory distress but hypoxemia has been reported in adults receiving IV intralipid infusions. To determine changes in pulmonary function during a 4 hr. intralipid infusion, 1 gm/kg intralipid was administered to 7 small premature neonates with mean wt. 1.16 kg (range 0.88-1.50) and mean gest. age 29 weeks. Arterial blood gases, func. resid. cap. (FRC), tidal volume (TV), resp. rate (RR), lung compliance (CL) and insp. (RI) and exp. (RE) pulmonary resistance, serum triglycerides (TG) and free fatty acids (FFA) were determined at control (pre-infusion), at 4 hours and at followup (4 hours after infusion). Control (mean ± SEM) FFA (0.58 ± .17) and TG (54.1 ± 6.3) increased at 4 hours to 2.0 ± 0.37 and 230.0 ± 66.2. Control PO2 (66.4 ± 11.1) decreased post infusion to 54.1 ± 2.1 mm Hg. At followup, both mean FFA and TG were higher than control values and less than post infusion. Mean ± SEM followup PO2 (62.6 ± 6.4) was higher than post infusion but lower than controls. There were no significant differences in pCO2, pH, base excess, RR, VT, min. vent., CL, RI, RE, or FRC for all 3 parts of the study. This study indicates that intralipid infusion in premature neonates affects PO2 but does not cause quantitative changes in other blood gas parameters or pulmonary function.
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Fox, W., Pereira, G. & Schwartz, J. 961 EFFECTS OF INTRALIPID INFUSIONS OF ARTERIAL BLOOD GASES AND PULMONARY FUNCTION IN SMALL PREMATURE NEONATES. Pediatr Res 12 (Suppl 4), 524 (1978). https://doi.org/10.1203/00006450-197804001-00967
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DOI: https://doi.org/10.1203/00006450-197804001-00967