Abstract
To determine the response of VLBW infants(<1.3 kg) to changes in Ca and P intake (postnatal age 2 to 6 wks), we measured net acid excretion (NAE), titratable acidity (TA) and ≥ on 24-hr urines collected on 45 thriving VLBW infants receiving SMA S26 (Wyeth Corp.), 80 cal/dl, 200 ml/kg/24 hr daily. The Ca/P intake (mg/kg) was: Group 1: 100/80; Gp. 2: 250/80; Gp. 3: 210/80; Gp. 4: 210/120. Gps. 1 and 2 received a Na intake of 1.5 mEq/kg/24 hr; Gps. 3 and 4 3 mEq/kg/24 hr, the difference as bicarbonate. Table shows results (mean±SEM) (*p<0.001) for baseline (2-3 wks) and study collections (4-6 wks).
Despite the 4-fold increase in Ca net retention in Gp. 2 compared to Gp. 1, H+excretion did not increase. Added NaHCO3 decreased TA and ≥, and P-supplements increased TA and NAE. TA and urinary P-excretion were correlated in Gps. 3 and 4 (y=-0.24+0.33×) (*). Thus, VLBW infants respond appropriately to NaHCO3 and P-supplement with respect to H-ion excretion.
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Cifuentes, R., Balfe, J. & Radde, I. 840 URINARY H+EXCRETION IN VERY LOW BIRTHWEIGHT(VLBW) INFANTS. EFFECT OF ALTERING Ca AND P INTAKE. Pediatr Res 12 (Suppl 4), 503 (1978). https://doi.org/10.1203/00006450-197804001-00845
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DOI: https://doi.org/10.1203/00006450-197804001-00845