Abstract
Between July 1976 and June 1977, 236 hospitalized patients (116 gastroenteritis “GE” and 120 control “C”), and an outpatient population of 85 patients (36 “GE” and 49 “C”) were studied for evidence of infection with bacterial enteric pathogens, enterotoxins and viruses. 46% of “GE” inpatients and 42% of “GE” outpatients, 15% of “C” inpatients and 14% “C” outpatients had potential enteric pathogens. HRV was the most commonly detected agent in gastroenteritis (36% of 152). Using the Y-l mouse adrenal CA assay, at least 4 isolates from each patient were tested for LT production. 120 were also tested by a radioimmunoassay (RIA) for LT. LT-producing (LT+) coliforms were found in 8% of hospitalized “GE” vs. 4% of hospitalized “C.” No difference in LT detection rate was noted in the “GE” outpatient vs. their outpatient “C.” LT-producing organisms were found in 7.6% of all gastroenteritis patients and 4% of controls. Among hospitalized HRV negative “GE,” 8.4% (6/71) had LT+ as opposed to 3% (3/110) “C” subjects. Approximately 90% of patients with LT+ coliforms were younger than 2 years of age. A limited number of patients have had their sera tested (by a blocking RIA test) for evidence of infection with LT. Only 12% (1/8) have had fourfold seroconversion following illness associated with recovery of coliform producing LT. LT's role in the mediation of gastroenteritis in our population needs to be further elucidated.
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Rodriguez, W., Kim, H., Greenberg, H. et al. 810 HUMAN ROTAVIRUS (HRV) AND HEAT LABILE ENTEROTOXIN (LT) DETECTION IN A PEDIATRIC POPULATION. Pediatr Res 12 (Suppl 4), 498 (1978). https://doi.org/10.1203/00006450-197804001-00815
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DOI: https://doi.org/10.1203/00006450-197804001-00815