Abstract
Changes in serum [Ca], [Mg] and [P] during 4 hr OGTT in 54 normal children and adolescents (N) were compared to borderline (B), chemical diabetes (C) and normal (AN) tests in 69 youngsters who had had at least one abnormal test. 38 of the pts. had siblings with overt DM and the rest were ascertained through the finding of glucosuria or hyperglycemia. Mean maximal % decline in [Ca] in 49 AN tests (7.4 ± .7 SEM), 28 B tests (7.2 ± .8) and 53 C tests (6.3 ± .6) differed at the <.005 level from N (12.9 ± 1.02). [Mg] average % maximal decline was similar to that of Ca for each group (N-11.8 ± 1.2, AN-7.1 ± 1.0, B-6.7 ± 1.0, C-5.3 ± .6). There were no significant differences in maximum [P] decreases (N-17.1% ± 1.4, AN-16.4 ± 1.2, B-15.9 ± 1.9, C-17.8 ± 1.5). Analysis of average % decline at each sampling time in the OGTT also revealed significantly less decline for Ca and Mg at all points after glucose intake, except 4 hr for Mg, during AN, B and C tests. [P] declined to a significantly greater degree at ½ hour in B and C tests and at 3 and 4 hours in C tests than N, consistent with known inverse relationship between glycemia and phosphatemia. None of these differences could be attributed to initial Ca, Mg and P levels, which were significantly low only in C tests. Marked diminution in hypocalcemic and hypomagnesemic effect of normal OGTT in persons presumed to have preclinical diabetes implies a metabolic derangement that precedes inappropriate maintenance of glycemia in DM.
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Rosenbloom, A., Rennert, O. SERUM CA AND MG DECLINE DURING ORAL GLUCOSE TOLERANCE TESTING (OGTT) IN PRE-CLINICAL DIABETES MELLITUS (DM) IS LESS THAN IN NORMALS. Pediatr Res 11, 521 (1977). https://doi.org/10.1203/00006450-197704000-00907
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DOI: https://doi.org/10.1203/00006450-197704000-00907