Abstract
Shifts in human lymphocyte subpopulations have been observed after exercise, following injection of steroids or epinephrine & diurnally. The present study evaluates the effect of a nutritional stimulus on peripheral blood lymphocytes. Six fasting normal subjects were given a ‘milkshake’ supplying one-third of the estimated daily caloric requirement, with defined amounts of carbohydrate, fat end protein. Heparinized blood samples were analysed for WBC & differential counts,percentages of E rosettes, Fc rosettes, C3 receptors and surface immunoglobulin (SmIG) prior to and at 30',60' and 120' after the stimulus. Lymphocyte subpopulation analysis results are shown below, expressed as total/mm3.
WBC and differential counts were not significantly altered, nor were numbers of E and Fe resetting cells. There were sustained decreases in cells with C3 receptors and SmIG. after the oral stimulus, during the time period studied. These changes did not occur in fasting individuals. There was no correlation with glucose levels. These changes may represent an alteration in lymphocyte recirculation induced by intestinal antigenic stimulation or post prandial hormonal alteration.
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Reece, E., Kan, W., Elsen, A. et al. LYMPHOCYTE SUBPAPULATIONS FOLLOWING ORAL NITRITIONAL STIMULI. Pediatr Res 11, 493 (1977). https://doi.org/10.1203/00006450-197704000-00737
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DOI: https://doi.org/10.1203/00006450-197704000-00737