Abstract
Elevated urinary polyamines have been demonstrated in a variety of untreated clinical cancers. SFPA levels in 20 lambda native serum samples obtained from normal (N) and cancer (CA) patient specimens were determined by anti-spermine antibody radio immunoassay (RIA). Levels of PA are expressed as nanogram of free spermine base per ml of fluid.
Values as high as 30 times normal have been encountered in pediatric and adult age cancer patients, occasionally in those classified as in remission. All CA patients were unselected, the opportunity for study occuring at various stages of diagnosis, clinical course and therapy. Nevertheless, intergroup comparisons of CA and N subjects revealed p values of 0.05 or less in all analyses. Preliminary results from a prospective study of newly diagnosed (untreated) lung cancer patients, n=8 demonstrated 7/8 with elevated SFPA values. SFPA elevations appear to be the rule in patients with a variety of liquid and solid tumors.
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Campbell, R., Bartos, F., Bartos, P. et al. SERUM FREE POLYAMINES (SFPA) LEVELS IN CANCER PATIENTS. Pediatr Res 11, 469 (1977). https://doi.org/10.1203/00006450-197704000-00593
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DOI: https://doi.org/10.1203/00006450-197704000-00593