Abstract
The technique of deep hypothermia (DH) for cardiac surgery results in altered renal and cardiac function: low flows and high resistances. We studied the effects of dopamine infusion (6.1 to 7.5 ug/kg/min) on renal and cardiac hemodynamics in 6 dogs during surface cooling to 20°C rectal (DH) under ether anesthesia; 6 control dogs received no dopamine. Open chest dogs were studied with electromagnetic flow probes on the aortic root and left renal artery. Data were recorded every 2° from normothennia (38°) to 20°C. Dopamine had no significant effects on the hemodynamic parameters. From normothennia to 20°C (DH) there were net decreases in heart rate (81%), mean aortic pressure (44%), cardiac output (667.), renal flow (75%) and pre-ejection period (PEP)/left ventricular ejection time (LVET) (55%). Net increases occurred in renal resistance (256%) and systemic resistance (210%), PEP (180%), and LVET (370%). Stroke volume and LV ejection work increased significantly (p<0.005) to 28°C and then decreased to normothermic values at 20°C. The data indicate no effect of dopamine in the usual clinical doses. Hypothermia resulted in increased inotropic state to 28°C and marked decreases in cardiac and renal hemodynamics at 20°C. We hypothesize that below 28°C, decreased myocardial compliance is an important factor in the decreased inotropism.
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Nielsen, D., Ruttenberg, H. EFFECTS OF DOPAMINE ON RENAL AND CARDIAC HEMO-DYNAMICS DURING DEEP HYPOTHERMIA. Pediatr Res 11, 396 (1977). https://doi.org/10.1203/00006450-197704000-00161
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DOI: https://doi.org/10.1203/00006450-197704000-00161