Abstract
There is general agreement that long-term hypoxemia stimulates the renin-angiotensin system, but the effects of short-term hypoxemia are less certain. For these reasons, we measured plasma renin activity (PRA) by radioimmunoassay in 14 hypoxemic infants, age 2-3 days, with severe respiratory distress syndrome (RDS). The same studies were repeated 5-7 days later, after the infants' condition had improved markedly. Comparisons were also made with a group of age and weight matched normal premature infants (n=6), and with a group of age matched normal term infants (n-10). The following results (meanĀ±SE) were obtained.
The PRA in the 2-3 day old infants with severe RDS did not correlate significantly with their PO2; and did not differ significantly from the PRA levels obtained following their clinical improvement 5-7 days later. Moreover, the PRA in the RDS infants did not differ significantly from the levels in the normal premature and term infants. Thus, short-term hypoxemia secondary to RDS does not appear to stimulate PRA.
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Siegler, R., Walker, M., Jubiz, W. et al. PLASMA RENIN ACTIVITY IN THE RESPIRATORY DISTRESS SYNDROME. Pediatr Res 11, 579 (1977). https://doi.org/10.1203/00006450-197704000-01256
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DOI: https://doi.org/10.1203/00006450-197704000-01256