Abstract
Twenty-three children with IRMCHNS received Cyclophosphamide for eight weeks in a single dose of 2 mg/kg/day. Patients ware divided according to their Prednisone response pattern: (a) steroid dependent (SD)-- relapse occurred while Prednisone was being tapered, and (b) frequent relapser (FR)--at least three relapses in six months or four within a year, each occurring after Prednisone had been completely tapered.
The remission rate after Cyclophosphamide was as follows:
The combined group remission rate is similar to those published in the literature. The difference in remission rate between FR and SD is significant (p <0.05). The efficacy of cyclophosphamide in the SD patient is open to further study.
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Garin, E., Pryor, N., Fennell, R. et al. IDIOPATHIC, RELAPSING, MINIMAL CHANGE NEPHROTIC SYNDROME OF CHILDHOOD (IRMCHNS): CYCLOPHOSPHAMIDE EFFICACY RELATED TO PREDNISONE RESPONSE PATTERN. Pediatr Res 11, 550 (1977). https://doi.org/10.1203/00006450-197704000-01084
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DOI: https://doi.org/10.1203/00006450-197704000-01084