Abstract
In view of the prevalence of intraventricular hemorrhage (IVII) as a cause of neonatal demise, the cardiovascular responses to experimental IVII were studied. 18 piglets ranging in age from birth to 16 days were anesthetized with 0.25% halothane in an H2O-O2 mixture and artificially ventilated. Blood gas parameters were controlled. Aortic pressure (AoP), spinal fluid pressure (SFP), heart rate (HR), and femoral, renal and carotid flows were recorded continuously. IVH was simulated by serial injections of 0.5 ml of blood into the right lateral ventricle. Norepinephrine was used to test responsiveness of peripheral receptors. Age-dependency of effects was evaluated statistically for all parameters. A total of 4.0 ml IVH with at least 70% increase in SFP led to a maximum of 59% increased mean AoP; and 50% increased HR in all piglets younger than 5 days of ane. Renal resistance (R) increased at all ages but femoral R did not. Carotid R increased 16.0%±3.9 in animals 4 days old or less and 49.6%±10.4 in one week old animals. Immaturity of the cardiovascular regulatory system was apparent as an absence of the adult pattern of response to increased SFP during IVH in the piglets. There was a precipitous fall in cardiovascular parameters just before the demise of the animal resembling that seen in terminal infants.
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Weinhouse, E., Gootman, N., Buckley, B. et al. CARDIOVASCULAR RESPONSES TO INTRAVENTRICULAR HEMORRHAGE IN NEONATAL PIGLETS. Pediatr Res 11, 544 (1977). https://doi.org/10.1203/00006450-197704000-01046
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DOI: https://doi.org/10.1203/00006450-197704000-01046