Abstract
In literature a negative correlation between PRA and chronological age has been reported for children. Sodium balance has not been considered in most cases. In adults negative correlation between PRA and Sodium excretion has been clearly documented. A nomogram plotting PRA in normal children, of various ages, in supine and upright positions against the daily rate of urinary Sodium at equilibrium would be desirable. In such a way we investigated a group of normal children, 26 to date; ages 50 days -13 yrs;dieted with constant Kalium (50 mEq/m2/24hrs.) and different-Sodium contents (15-150 mEq/m2/24hrs).
Results: regression equations calculated on plotted values show a similar adult-trend. Supine PRA are poorly, whereas upright PRA values are highly related to Sodium intake. A linear correlation is justified in the former; in the latter, a parabolic (or hyperbolic?) correlation consistently reduces the variance.
Evidence arises that supine PRA has a limited significance, in individual cases, considering its wide variability also after normalization for Sodium intake.
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Giovannelli, G., Banchini, G. 172: Relationship between PRA and Sodium intake in normal children. Pediatr Res 10, 899 (1976). https://doi.org/10.1203/00006450-197610000-00163
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DOI: https://doi.org/10.1203/00006450-197610000-00163