Abstract
TRH (200 μg/1.73 m2, i.v.) was given to 89 normal, subjects (43 males anrl 46 females; ages: 2.5-81 yrs.), 7 Klinefelter's (K.s.) and 11 Turner's (T.s.) syndromes. TSH and PRL response were evaluated using Δ as well as the incretory area: results were fairly similar with both methods. TSH response decreases with age (the difference is significant between children and aged subjects in both sexes); its behaviour is similar in males and females; T.s. and K.s. behave as normal subjects of the same age. As for PRL, its correlation with sex is evident; higher values in. females than in males and, among the former, higher in adult than in prepuberal subjects. Moreover, PRL levels in T.s. are lower and in K.s. higher than those of adult subjects of corresponding sex. In conclusion: after TRH i.v, PRL response seems to be influenced by gonadal activity (oestrogens dependent?); while TSH shows no correlation with varying oestrogens levels, such as is found in physiological or in (tested) pathological conditions.
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Bernasconi, S., Giovannelli, G., Valenti, G. et al. 110: TSH and PRL response to TRH: correlation with age, sex, and gonadal activity. Pediatr Res 10, 888 (1976). https://doi.org/10.1203/00006450-197610000-00101
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DOI: https://doi.org/10.1203/00006450-197610000-00101