Extract: A comparative study of two smallpox vaccines, standard calf lymph vaccine, and an attenuated vaccine, CVI-78, was performed in 95 children. Primary vaccination with CVI-78 resulted in a more attenuated response than primary vaccination with standard vaccine. Sixty-one percent of those vaccinated with CVI-78 and 96% of those vaccinated with standard vaccine developed a major dermal reaction; 16% of those vaccinated with CVI-78 and 89% of those vaccinated with standard vaccine developed postvaccination neutralizing antibodies. Twenty-seven percent of the children vaccinated with CVI-78 demonstrated neither a dermal nor serologic postvaccination response, whereas only 2% of those vaccinated with standard vaccination demonstrated no postvaccination response.
Speculation: Smallpox vaccine strain CVI-78 produces a modified local and serologic reaction in children. This vaccine may be overattenuated and thus is not useful as a replacement for standard vaccine. The vaccine in limited circumstances may be useful as a protective vaccine for those who might be expected to develop complications after challenge with standard vaccine. This speculation requires further study.
About this article
Cite this article
Wesley, R., Speers, W., Neff, J. et al. Evaluation of Two Kinds of Smallpox Vaccine: CVI-78 and Calf Lymph Vaccine: I. Clinical and Serologic Response to Primary Vaccination. Pediatr Res 9, 624–628 (1975). https://doi.org/10.1203/00006450-197508000-00002
- vaccine, calf lymph
- vaccine, CVI-78
- vaccinia virus