Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Evaluation of Two Kinds of Smallpox Vaccine: CVI-78 and Calf Lymph Vaccine: I. Clinical and Serologic Response to Primary Vaccination

Abstract

Extract: A comparative study of two smallpox vaccines, standard calf lymph vaccine, and an attenuated vaccine, CVI-78, was performed in 95 children. Primary vaccination with CVI-78 resulted in a more attenuated response than primary vaccination with standard vaccine. Sixty-one percent of those vaccinated with CVI-78 and 96% of those vaccinated with standard vaccine developed a major dermal reaction; 16% of those vaccinated with CVI-78 and 89% of those vaccinated with standard vaccine developed postvaccination neutralizing antibodies. Twenty-seven percent of the children vaccinated with CVI-78 demonstrated neither a dermal nor serologic postvaccination response, whereas only 2% of those vaccinated with standard vaccination demonstrated no postvaccination response.

Speculation: Smallpox vaccine strain CVI-78 produces a modified local and serologic reaction in children. This vaccine may be overattenuated and thus is not useful as a replacement for standard vaccine. The vaccine in limited circumstances may be useful as a protective vaccine for those who might be expected to develop complications after challenge with standard vaccine. This speculation requires further study.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wesley, R., Speers, W., Neff, J. et al. Evaluation of Two Kinds of Smallpox Vaccine: CVI-78 and Calf Lymph Vaccine: I. Clinical and Serologic Response to Primary Vaccination. Pediatr Res 9, 624–628 (1975). https://doi.org/10.1203/00006450-197508000-00002

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1203/00006450-197508000-00002

Keywords

  • Smallpox
  • vaccine, calf lymph
  • vaccine, CVI-78
  • vaccinia virus

Search

Quick links