Abstract
Urinary LDH isoenzyme assays were performed in patients with proven kidney(N-15) and bladder(N-15) infections as well as normal controls(N-24). Documentation of bladder and kidney infection was accomplished by means of the Bladder Washout Test, culture of ureteric urine(urinary diversion), maximal urine concentration test, clinical symptomatology and radiologic appearance of the urinary tract. U-LDH in normal children(10.8±1.0uU/ml) was significantly lower than in patients with bladder (23.1 ± 4.4uU/ml), or kidney(231.2±72.2uU/ml) infections (p<0.05). In the normal population most of the enzyme activity was comprised among isoenzymes I and II (fast zone pattern). In patients with bladder infection both fast and slow zone patterns were observed, but the actual level of isoenzyme V(4±3.8) was significantly lower than in patients with kidney infections (116±165) where a slow zone pattern was invariably seen(p<0.05). Since overlap occured in only one patient, a correct differential diagnosis of kidney and bladder infections would have been possible in 96.6% of the cases.
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Carvajal, H., Passey, R., Berger, M. et al. URINARY LDH ISOENZYMES IN THE DIFFERENTIAL DIAGNOSIS OF KIDNEY AND BLADDER INFECTIONS. Pediatr Res 8, 454 (1974). https://doi.org/10.1203/00006450-197404000-00683
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DOI: https://doi.org/10.1203/00006450-197404000-00683