Abstract
Nineteen infants with hyaline membrane disease (HMD) were studied to determine if the time of initiation of continuous negative pressure(CNP) affected the course of the disease. All infants had an initial PaO2 between 50-100mmHg on 0.7FiO2. They were then randomly assigned to one of two groups: the early-onset group (n=9, mean B.W. 1626 Grams) started on CNP while the PaO2 was between 50-100mmHg on 0.7FiO2; the late-onset group (n=10, mean B.W. 1866 Grams) started on CNP after the PaO2 fell below 50mmHg on 0.7FiO2. Results are as follows:
The early-onset group responded better to CNP in terms of the initial increase in PaO2 (ΔPaO2), required a shorter period of oxygen therapy, and needed a shorter period of ventilatory assistance which consisted only of CNP. Three of the late-onset group required mechanical ventilation and four had either pneumomediastinum, pneumothorax, patent ductus arteriosus requiring ligation, or right diaphragmatic paralysis. There were no complications in the early-onset group. This study indicates that it is desirable to begin CNP as soon as possible in infants witli HMD.
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Mockrin, L., Bancalari, E. & Cleveland, W. CONTINUOUS NEGATIVE PRESSURE IN HYALINE MEMBRANE DISEASE: EARLY VERSUS LATE ONSET. Pediatr Res 8, 448 (1974). https://doi.org/10.1203/00006450-197404000-00649
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DOI: https://doi.org/10.1203/00006450-197404000-00649