Abstract
Glucose malabsorption has been produced in experimental animals fed free bile acids. For this reason it is important to investigate the role of duodenal free bile acid concentrations in infants with AMI. Four subjects who manifested dehydrating diarrhea with acid stools and free fecal glucose in response to a 5 % glucose electrolyte mix were studied. They were compared to 5 infants with Acute non-pathogenic Diarrhea (AD). Duodenal samples were processed by gas-liquid chromatography for free and conjugated bile acids. Glucose absorption was studied by infusing a 10 % solution with 1 % PEG through a double lumen tube in the jejunum. Samples were recovered at 15 minutes intervals from a 30 cm. distal site. Total unconjugated bile acids (μg/ml) were 20.1 ± 8 in normal controls, 58.4 ± 27 in infants with AD and 319 ± 134 in AMI. A linear correlation exists between the concentration of free bile acids of the intestinal fluid and glucose transport ratef (r = 0.79 ). These observations support the role of altered bile acid metabolism in acquired glucose malabsorption.
Work supported by: David Underwood Trust, NASA Contract 90059. NTH RR 00188, Mead Johnson Laboratories and AMA Goldberger Fellowship.
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Rodriguez, J., Huang, T., Alvarado, J. et al. ROLE OF FREE BILE ACIDS IN ACQUIRED MONOSACCHARIDE INTOLERANCE (AMI). Pediatr Res 8, 385 (1974). https://doi.org/10.1203/00006450-197404000-00269
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DOI: https://doi.org/10.1203/00006450-197404000-00269